1) A good GUI design for a BLAG specific DTP package
Have you tried Scribus?http://www.scribus.net/
2) running off Gnome is good, but what about a Suite that holds all the tools novices could use to do some cool stuf.
What tools are you after? As far as I can tell Gnome doesn't lack anything critical found either in Windows or Mac. If you mean a suite like Macromedia Suite then I am unaware of one existing. However with Windows I never used Macromedia apps together anyways. So seperate apps for seperate jobs is what I am used to and I haven't noticed any difference.
3) A good WYSIWYG html / Graphics / Web layout tool, like the Macromedia Studio Suite
Mozilla Composer has WYSIWYG capabilities.
Also here is a review of IMB Homepage Builder.http://www.linuxlookup.com/html/reviews ... re4.0.html
I haven't tried it myself since I write the HTML but give it a go and see if it helps you.
4) A graphic designers raster based editor GIMP lacks CMYK abilities, and some ease of use features for those of us not tech enuff
GIMP has a CMYK plugin you can use.
Good luck and I hope you find something you like.